Healthy aging gut support - AB INTRA Gutbiotica PRIME - main image
AB INTRA Gutbiotica PRIME packaging with its powder and Bifidobacterium in the background
AB INTRA Gutbiotica PRIME - Why it works
AB INTRA Gutbiotica PRIME - How to use and acclimatization
Healthy aging gut support - AB INTRA Gutbiotica PRIME - main image
AB INTRA Gutbiotica PRIME packaging with its powder and Bifidobacterium in the background
AB INTRA Gutbiotica PRIME - Why it works
AB INTRA Gutbiotica PRIME - How to use and acclimatization

Gutbiotica PRIME

A next‐generation gut support formula designed specifically for healthy aging. With a synergistic blend of 2’-fucosyllactose, human-residential Bifidobacterium strains, and MGCPQQ®, Gutbiotica PRIME supports microbiome resilience and vitality as we age.

 119,95 incl. VAT

30 day supply

In stock

Free NL shipping from €75. For other countries: Shipping Policy.

What Gutbiotica PRIME does:

  • Targets beneficial Bifidobacteria with 2’-fucosyllactose.
  • Delivers 10 billion CFU Triple Bifidus probiotic blend.
  • Provides 20 mg MGCPQQ®, a nutrient with antioxidant potential.

Science backed and
premium ingredients

No refrigeration
needed

Tasteless,
easy to consume

How It Works

Selective Prebiotic Action

3000 mg of 2’-fucosyllactose selectively nourishes Bifidobacterium species, thanks to their unique glycoside hydrolase and transferase enzymes that can metabolize 2’-FL [1,2]. These beneficial microbes often decline with age [3,4], making targeted support essential.

Triple Bifidus Probiotic

10 billion CFU of clinically studied, human-residential Bifidobacterium strains: B. longum BB536 (5B CFU), B. breve M-16V (2.5B CFU), B. infantis M-63 (2.5B CFU). Naturally selected by human milk, these strains promote diversity and cross-talk in the gut ecosystem, supporting stability and resilience [5,6].

MGCPQQ®

20mg of MGCPQQ®, the only PQQ approved as a novel food ingredient in the EU.

MGCPQQ®  is a registered trademark of MGC (Japan).

We can’t always add years to life, but we can add more life to our years. Gutbiotica PRIME is inspired by the science of longevity, supporting microbiome balance and cellular vitality as you age.

Key Ingredients

2'-FUCOSYLLACTOSE

One of the most abundant human milk oligosaccharides (HMOs) [7]. The majority of ingested 2’-FL reaches the colon, where it acts as a selective fuel for Bifidobacteria, earning its recognition as a prebiotic [8,9].

MGCPQQ®

The only PQQ approved as a novel food ingredient in the EU.

TRIPLE BIFIDUS PROBIOTIC

A synergistic mix of B. longum, B. breve, and B. infantis—inspired by the microbial diversity found in early life. Together, they enhance microbial cross-talk and promote cross-feeding: the sharing of beneficial metabolites with other species. This cooperation boosts microbiome adaptability and strengthens gut ecosystem resilience across varying conditions [6,10,11].

  1. V. Bunesova, C. Lacroix, and C. Schwab, “Fucosyllactose and L-fucose utilization of infant Bifidobacterium longum and Bifidobacterium kashiwanohense,” BMC Microbiol., vol. 16, no. 1, p. 248, 2016, doi: 10.1186/s12866-016-0867-4.
  2. F. Turroni, C. Milani, S. Duranti, J. Mahony, D. van Sinderen, and M. Ventura, “Glycan Utilization and Cross-Feeding Activities by Bifidobacteria,” Trends Microbiol., vol. 26, no. 4, pp. 339–350, Apr. 2018, doi: 10.1016/j.tim.2017.10.001.
  3. S. Arboleya, C. Watkins, C. Stanton, and R. P. Ross, “Gut Bifidobacteria Populations in Human Health and Aging,” Front. Microbiol., vol. 7, 2016.
  4. T. S. Ghosh, F. Shanahan, and P. W. O’Toole, “The gut microbiome as a modulator of healthy ageing,” Nat. Rev. Gastroenterol. Hepatol., vol. 19, no. 9, pp. 565–584, 2022, doi: 10.1038/s41575-022-00605-x.
  5. C. B. Wong, T. Odamaki, and J. Xiao, “Beneficial effects of Bifidobacterium longum subsp. longum BB536 on human health: Modulation of gut microbiome as the principal action,” J. Funct. Foods, vol. 54, pp. 506–519, 2019, doi: https://doi.org/10.1016/j.jff.2019.02.002.
  6. C. B. Wong, T. Odamaki, and J. Xiao, “Insights into the reason of Human-Residential Bifidobacteria (HRB) being the natural inhabitants of the human gut and their potential health-promoting benefits,” FEMS Microbiol. Rev., vol. 44, no. 3, pp. 369–385, May 2020, doi: 10.1093/femsre/fuaa010.
  7. R. M. Erney et al., “Variability of Human Milk Neutral Oligosaccharides in a Diverse Population,” J. Pediatr. Gastroenterol. Nutr., vol. 30, no. 2, pp. 181–192, Feb. 2000, doi: https://doi.org/10.1002/j.1536-4801.2000.tb02700.x.
  8. J. J. Ryan, A. Monteagudo-Mera, N. Contractor, and G. R. Gibson, “Impact of 2′-Fucosyllactose on Gut Microbiota Composition in Adults with Chronic Gastrointestinal Conditions: Batch Culture Fermentation Model and Pilot Clinical Trial Findings,” Nutrients, vol. 13, no. 3. 2021, doi: 10.3390/nu13030938.
  9. E. Elison et al., “Oral supplementation of healthy adults with 2′-O-fucosyllactose and lacto-N-neotetraose is well tolerated and shifts the intestinal microbiota,” Br. J. Nutr., vol. 116, no. 8, pp. 1356–1368, 2016, doi: DOI: 10.1017/S0007114516003354.
  10. L. Oña, S. Giri, N. Avermann, M. Kreienbaum, K. M. Thormann, and C. Kost, “Obligate cross-feeding expands the metabolic niche of bacteria,” Nat. Ecol. Evol., vol. 5, no. 9, pp. 1224–1232, 2021, doi: 10.1038/s41559-021-01505-0.
  11. M. Xiao et al., “Cross-feeding of bifidobacteria promotes intestinal homeostasis: a lifelong perspective on the host health,” npj Biofilms Microbiomes, vol. 10, no. 1, p. 47, 2024, doi: 10.1038/s41522-024-00524-6.
  12. T. Odamaki et al., “Age-related changes in gut microbiota composition from newborn to centenarian: a cross-sectional study,” BMC Microbiol., vol. 16, no. 1, p. 90, 2016, doi: 10.1186/s12866-016-0708-5.

Supporting What Time Takes Away: Bifidobacteria Through the Years

We begin life rich in Bifidobacteria, but their abundance naturally declines with age [3,4]. This decline is often accompanied by a drop in butyrate- and other SCFA-producing microbes [12]. Bifidobacteria play an important upstream role by producing lactate and acetate [11], essential substrate for butyrate-producing bacteria such as Eubacterium, Faecalibacterium prausnitzii, and Roseburia species.

Gutbiotica PRIME delivers human-residential Triple Bifidus strains and 2’-FL to selectively nourish these beneficial microbes and help maintain microbial resilience throughout life’s later stages.

Figure of Bifidobacteria levels across the human lifespan is modified from Arboleya et al., 2016, Frontiers in Microbiology (CC BY 4.0). Original figure by Arboleya, Watkins, Stanton and Ross.

Our Curated Pairings

Original price was: € 209,90.Current price is: € 179,95. incl. VAT

Complete beauty from within—Gutbiotica PRIME provides comprehensive microbiome support while Skinbiotica COLLAGEN+ promotes radiant and elastic skin.

Original price was: € 164,90.Current price is: € 139,95. incl. VAT

A smart pairing for gut microbiome and weight support with Gutbiotica CORE and Fibersentials SHAPE to maintain a happy gut and support satiety naturally.

 89,95 incl. VAT

Science-backed beauty from within: collagen tripeptides for the dermis, Ceramosides™ for the barrier, and probiotics + prebiotics for the gut-skin axis. All in one daily serving.

Can I take PRIME while pregnant or breastfeeding?

Gutbiotica PRIME is not recommended during pregnancy or while breastfeeding, due to the inclusion of MGCPQQ®. If you’re looking for gut support during this time, we suggest speaking with your healthcare provider about other options.

Yes, in most cases. Research shows that many individuals with lactose intolerance can tolerate up to 12 grams of lactose in a single serving, about the amount in a cup of milk. One serving of Gutbiotica PRIME contains less than 0.5 g of sugar, a portion of which is lactose. This is well below the typical tolerance threshold, making it suitable for most lactose-intolerant individuals when taken as directed.

Yes, it’s designed to support gut balance and cellular vitality as we age. But since biological ageing varies, it can benefit anyone looking to maintain resilience from within.

These strains, Bifidobacterium longum, Bifidobacterium breve, and Bifidobacterium infantis, are naturally adapted to the human gut and selected through evolutionary mechanisms. This makes them very compatible to us.

2’-fucosyllactose helps replenish beneficial Bifidobacterium populations, which tend to decline with age or poor diet. Its structure mimics the oligosaccharides found in human milk.

No. Gutbiotica PRIME does not contain human milk. The 2’-fucosyllactose (2’-FL) used is produced through a precise fermentation and purification process, resulting in a powder that is molecularly identical to the 2’-FL found in human milk. All the benefits—without any human-derived ingredients.

MGCPQQ®  is the only pyrroloquinoline quinone (PQQ) approved by the European Commission as a novel food ingredient. It also has regulatory approval in the US and Japan. PQQ is a coenzyme for dehydrogenase and is naturally present in small amounts in food and human milk.

No, Gutbiotica PRIME is shelf-stable.

Frequently
Asked Questions

Gutbiotica PRIME

 119,95 incl. VAT

Supplement Facts

AB INTRA Gutbiotica PRIME nutritional values and supplement facts panel

Ingredients

AB INTRA Gutbiotica PRIME - Ingredients list